Evolución de sunitinib en 1ª línea en CCRm: Esquemas alternativos - page 12

The Renal EFFECT Trial: Resultados
Sunitinib 50 mg/d
Schedule 4/2
(N=146)
Sunitinib 37.5 mg/d
CDD schedule
(N=143)†
Adverse Event, n (%) All grades Grade 3/4 All grades Grade 3/4
Fatigue 95 (65) 13 (9) 101 (71) 16 (11)
Nausea 92 (63) 4 (3) 77 (54) 9 (6)
Diarrhea 86 (59) 9 (6) 98 (69) 8 (6)
Dysgeusia 55 (38) 0 49 (34) 0
Vomiting 49 (34) 4 (3) 49 (34) 9 (6)
Hypertension 48 (33) 12 (8) 42 (29) 12 (8)
Decreased appetite 46 (32) 2 (1) 59 (41) 7 (5)
Hand-foot syndrome 46 (32) 14 (10) 36 (25) 15 (10)
Mucosal inflammation 41 (28) 3 (2) 36 (25) 3 (2)
Constipation 40 (27) 1 (<1) 40 (28) 2 (1)
Dyspepsia 37 (25) 2 (1) 36 (25) 0
Rash 36 (25) 2 (1) 44 (31) 2 (1)