MOLECULAR ALTERATIONS IN NON‐CLEAR CELL RCC ARE INVOLVED
IN HIF1 AND TOR PATHWAYS
α
m
MET
Ch
h b RCC
FNIP1
FNIP2
PI3K
Papillary I RCC
romop o e
FLCN
VEGF
mTOR
Fumarate
O
2
Receptors
PDGF
TGFα
HIF1α
hydratase
Fumarate
Malate
2‐oxiglutarate
Ub
TUMOR GROWTH
ANGIOGENESIS
Papillary II RCC
Prolyl
hydroxilase
HIF proteasome
E3 ubiquitin
VHL
Ub
Ub
Clear cell RCC
degradation
ligase
Modificado de Dr. I. Durán
