135 patients 34.8% experienced VTE
Menapace et al. Thromb Haemost. 2011;106(2):371-8
1915 patients 36% experienced VTE
Epstein et al. Cancer. 2012;118(12):3053-61
Abstract.
Background: Venous thromboembolism (VTE) is
associated with cancer. Cancer patient with thromboembolism
have poorer prognosis. This study assessed the risk and
mortality in pancreatic cancer patients who develop VTE.
Patients and Methods: A retrospective chart review was
performed of 201 patientswith pancreatic cancer. Results: VTE
was observed in 58 (28.9%) patients, 37/58 had deep vein
thrombosis (DVT), 11/58 pulmonary embolism (PE) and 10/58
had both. Twenty-six out of 107 patients with tumor of head of
the pancreas developed VTE (24%), compared to half of the
patients with body of the pancreas involvement (11-22). Stage
events. Lower-extremity deep venous thrombosis,
thrombophlebitis migrans, and pulmonary embolism are
among the well-known presentations in pancreatic cancer (2).
The first report describing the relationship between pancreatic
cancer and thrombosis was published in 1938, documenting a
60% prevalence of venous thrombosis in various locations
upon autopsy compared with 15-25% in other malignancies
(3) This makes pancreatic cancer the tumor entity with the
highest venous thromboembolism (VTE) rates. Further
studies have confirmed the association of pancreatic
adenocarcinoma with VTE reporting prevalence rates of 5 to
A
NTICANCER
R
ESEARCH
30
: 4261-4264 (2010)
Assessing Risk and M or tality of Venous
Thromboembolism in Pancreatic Cancer Patients
WALID SHAIB
1
, YANHONG DENG
1
, DANIEL ZILTERMAN
2
,
BRUCE LUNDBERG
1
and MUHAMMAD WASIF SAIF
3
1
Saint Raphael Hospital, New Haven, CT, U.S.A.;
2
Yale New Haven Hospital, New Haven, CT, U.S.A.;
3
Columbia University College of Physicians and Surgeons, New York, NY, U.S.A.
Stage IV PDAC 39% experienced VTE
Shaib et al. Anticancer Res. 2010;30(10):4261-4
84 patients 35.7% experienced VTE
Muñoz et et al. Clin Transl Oncol (2014) 16:927–930
Second preventable cause of death in cancer ptients
(Monreal M, 2016)
