PD-1 regulates inflammatory responses in
peripheral tissues
cancer
cell
•The PD1/PDL1 pathway is an immune checkpoint that suppresses activated T
cells and promotes tolerance
•PD1 receptor is expressed on T, B & NK cells
•Ligands are PDL1 & PDL2 expressed on APC and tumor cells
Lymph node
(Priming phase)
Peripheral tissue
(Effector phase)
