 
          
            Enzalutamide vs Bicalutamide in CRPC: The STRIVE trial
          
        
        
          
            Primary endpoints:
          
        
        
          
            l
          
        
        
          
            id
          
        
        
          
            Patient population:
          
        
        
          
            Progression‐free 
          
        
        
          
            survival:
          
        
        
          
            Enza utam e
          
        
        
          
            160 mg/day
          
        
        
          
            (capsules) 
          
        
        
          
            n 198
          
        
        
          
            R
          
        
        
          
            A
          
        
        
          
            N
          
        
        
          •
        
        
          
            M0 or M1 CRPC
          
        
        
          •
        
        
          
            Asymptomatic/
          
        
        
          
            mildly symptomatic
          
        
        
          ‐
        
        
          
            Radiographic
          
        
        
          
            progression
          
        
        
          
            or
          
        
        
          
            =
          
        
        
          
            D
          
        
        
          
            O
          
        
        
          
            M
          
        
        
          
            I
          
        
        
          •
        
        
          
            Chemotherapy‐naïve
          
        
        
          •
        
        
          
            No prior bicalutamide or no 
          
        
        
          
            progression on bicalutamide
          
        
        
          ‐
        
        
          
            PSA progression
          
        
        
          
            or
          
        
        
          
            Death
          
        
        
          
            Bicalutamide
          
        
        
          
            Z
          
        
        
          
            E
          
        
        
          
            D
          
        
        
          ‐
        
        
          
            50 mg/day
          
        
        
          
            N=198
          
        
        
          
            1:1
          
        
        
          Penson D, et al. J Clin Oncol 2016