Trials (with results) with Enzalutamide in CRPC
STRIVE
TERRAIN
PREVAIL
AFFIRM
Population
M0, M1
M1
M1
M1
Previous chemo
NO
NO
NO
YES
Progression on previous
NOT ALLOWED
NOT ALLOWED
ALLOWED
ALLOWED
bicalutamide
Median time to PSA
progression
NR
19.4 m
11.2 m
8.3 m
Median rPFS
NR (M1)
NR
20 m
8.3 m
Median OS
NR
NR
35.3 m
18.4 m
