PAM50 Generates an Risk Of Relapse (ROR)
Score Specific to Each Patient
•
Intrinsic subtype + Proliferation score + Tumor size
.
•
“Training cohort”:
–
Patients with tumors representing all subtypes.
–
Pre (
30%) and post-menopausal patients.
–
None received adjuvant systemic therapy.
Parker et al. JCO 2009; Nielsen et al. CCR 2010
Patient
expression
profile
PAM50 centroids
Pearson’s
correlation to
centroids
Proliferation score
Tumor size
