What is coming up next in 1L?
IMvigor130 (NCT02807636)
Gemcitabine/carboplatin +
placebo
Gemcitabine/carboplatin +
atezolizumab
•
1L cisplatin-ineligible
•
ECOG PS ≤2
•
Locally advanced/metastatic
N=435
R
Co-primary endpoints: PFS and OS
KEYNOTE-361 (NCT02853305)
Cisplatin + gemcitabine or
carboplatin + gemcitabine
Pembrolizumab + cisplatin/gemcitabine or
Pembrolizumab + carboplatin/gemcitabine
Co-primary endpoints: PFS and OS
•
1L unresectable or
metastatic UC
•
ECOG PS ≤2
N=990
Pembrolizumab
R
DANUBE (NCT02516241)
SOC CT:
cisplatin + gemcitabine or
carboplatin + gemcitabine
Durvalumab + tremelimumab
•
1L unresectable stage IV
UBC
•
Eligible / ineligible for
cisplatin-based CT
N=525
Durvalumab
R
Primary endpoint: OS
