AKT, alpha serine/threonine-protein kinase; CDK4/6, cyclin-dependent kinase 4/6;
DDR2, discoidin domain receptor tyrosine kinase 2; EGFR, epidermal growth factor receptor;
FGFR, fibroblast growth factor receptor; NSCLC, non-small cell lung cancer;
PARP, polyadenosine diphosphate (ADP)–ribose polymerase;
PIK3CA, phosphatidylinositol 3-kinase catalytic subunit; PI3K, phosphoinositide-3-kinase;
PTEN, phosphatase and tensin homolog; RB, retinoblastoma;
RTK, receptor tyrosine kinase; SOX, SRY-related HMG box
1. Shtivelman E et al
. Oncotarget
2014;5:1392–433; 2. Stead LF et al
. PLoS One
2013;8:e78823
RTK
EGFR
amplification
FGFR1
amplification
DDR2 mutations
PI3K
PIK3CA
mutations
PTEN deletion
AKT1/2/3
overactivation
Developmental
SOX2
amplification /
SOX2
overexpression
DNA repair
PARP
RB
CDK4/6
Estudios en Marcha
