Cambio de paradigma en el EGFR mutado: desde las primeras mutaciones a las de resistencia - page 2

EGFR mutations in NSCLC
2
ACTIVATING
MUTATIONS
mainly
exon Del19
&
exon 21
L858R
Sharma SV, et al. Nat Rev Cancer 2007
• EGFR activating mutations clustered around the ATP-binding pocket of
the EGFR tyrosine kinase and leads to increased kinase activity