mRCC is a VEGF driven disease
‐
VEGF expression in ~6500 tissue specimens
6000
5000
4000
Vascularised, angiogenic tumour
Treatment with
angiogenesis inhibitor
Vessels begin
to regress
Tumour shrinks
3000
2000
1000
0
ation signal
VEGF-A mRNA
Judah Folkman
Adipose
Adrenal
oodvessel
Bone
nemarrow
Breast
Cervical
CNS
Colorectal
dometrium
esophagus
Gallbladder
ead& neck
Heart
Kidney
Liver
Lung
Lymphoid
Muscle
yometrium
oendocrine
Ovary
Pancreas
Pituitary
Placenta
Prostate
Skin
all intestine
Soft tissue
Stomach
Testis
Thymus
Thyroid
Urinary
WBC
Hybridis
intensity for
Z tt B N t R C 2008
J bb
J Cli P th l 2004
Bl
Bo
En
O
H
M
Neur
Sm
e er . a ev ancer
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