Nuevas dianas y riesgo de ETV
PEGPH20 – Hialuronidasa humana recombinante pegilada
PEGPH20'–'Hialuronidasa'humana'recombinante'pegilada'
NUEVASDIANAS EN CÁNCER DE PÁNCREASMETASTÁSICO
42% VTE PEGPH20+NP-GEM vs 25% NP-GEM
Clinical hold, protocol amendment
Add enoxaparin prohphylaxis
40 mg/day 13% - 1 mg/kg/day 0%
Tumor Microenvironment/Stroma: PEGPH
20
Randomized phase II trials underway
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Nab-P + gemcitabine +/- PEGPH20 (Halozyme)
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FOLFIRINOX +/- PEGPH20 (SWOG-NCI)
Phase III trial planned
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Nab-P + gemcitabine +/- PEGPH20
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Hyaluronan high
