31
CheckMate 017 (SQ NSCLC)
CheckMate 057 (non-SQ NSCLC)
42
24
43
25
44
25
45
26
47
26
0
20
40
60
80
100
Nivolumab
Docetaxel
Overall
PD-L1 expression
135 137
54 52
63 56
42 39
36 33
n
Overall
PD-L1 expression
51
39
45
39
60
37
66
32
67
30
0
20
40
60
80
100
290
292
108 101
123 123
95 86
86 79
n
OS (%)
All patients
0.59
(0.44, 0.79)
0.58
(0.37, 0.92)
0.69
(0.45, 1.05)
0.53
(0.31, 0.89)
0.50
(0.28, 0.89)
HR
b,3
(95% CI)
<1%
≥1%
≥5%
≥10%
All patients
0.73
(0.59, 0.89
c
)
0.90
(0.66, 1.24)
0.59
(0.43, 0.82)
0.43
(0.30, 0.63)
0.40
(0.26, 0.59)
HR
b,4
(95% CI)
<1%
≥1%
≥5%
≥10%
OS (%)
CheckMate 017 and CheckMate 057
1 year OS
PD-L1 medible en el 78% de las muestras: 54% PD-L1 +
