ORR and DOR in Patients with Measurable
Disease
Objective response rate (ORR)
Duration of response (DOR)
0.0
0.2
0.4
0.6
0.8
1.0
Proportion progression-free
0 2 4 6 8 10 12 14 16 18 20 22 24 26 28 30 32 34 36
Median, months (95% CI)
Cap + Lap
6.5 (5.5, 7.2)
T-DM1
12.6 (8.4, 20.8)
Difference: 12.7% (95% CI, 6.0, 19.4)
P
=0.0002
120 105 77 48 32 14 9 8 3 3 1 1 0 0 0 0
173 159 126 84 65 47 42 33 27 19 12 8 2 0 0 0
Cap + Lap
T-DM1
No. at risk
0
0
0
0
0
0
Time (months)
Patients, %
0
20
30
40
50
10
T-DM1
173/397
120/389
43.6%
30.8%
Cap + Lap
Verma S, NEJM 2012
