Lap+Tras
75
62
48
37
23
15
1
Lap
75
50
28
20
16
7
Lap+Tras
N=71
Lap
N=70
OS hazard ratio
(95% CI)
Median OS,
months
12.0
11.2
0.84
(0.5-1.23)
Lap+Tras
N=75
Lap
N=75
OS hazard ratio
(95% CI)
Median OS,
months
17.2
8.9
0.62
(0.42-0.90)
Lapatinib + trastuzumab
EGF104900: Overall survival by
hormone receptor status
•
CI = confidence interval; HR = hormone receptor; Lap = lapatinib; OS = overall survival; Tras = trastuzumab.
•
Tyverb Assessment report EMEA/H/C/000795/II/0022 2013. Available at:
_-
•
HR-positive
0
5
10
15
20
25
30
0.0
0.2
0.4
0.6
0.8
1.0
Time from Randomization (Months)
Cumulative Proportion Alive
Lap+Tras
Lap
HR-negative
Number at Risk
Lap+Tras
71
58
39
26
19
10
Lap
70
50
36
26
12
6
Blackwell K, JCO 2008
