Systemic therapy for patienst in > 2nd relapse and TFIp > 6 m
Is there any option for non-platinum based combination
(trabectedine-PLD)?
BRCA wt
•
Previous use of Beva or
Beva not used in 1st or
2nd line
•
TFIp < 12 months after
> 2nd relapse
•
No complete response
in previous line
Trabectine-PLD had better OS
than PLD in TFIp 6-12 m
45
44
44
39
36
32
23
18
16
12
12
11
8
7
6
3
2
1
1
0
0
49
49
48
47
45
43
39
34
29
25
22
19
17
14
11
8
5
3
3
0
0
PLD
T+PLD
Patients at risk
Cumulative probability
0.0
0.1
0.2
0.3
0.4
0.5
0.6
0.7
0.8
0.9
1.0
Time (months)
0
3
6
9 12 15 18 21 24 27 30 33 36 39 42 45 48 51 54 57 60
N=94
HR: 0.58 (0.37-0.90)
p=0.0153
Trabectedin+PLD
Median=27.7 mos
PLD
Median=18.7 months
Colombo N, et al. Int J Gynecol Cancer [Internet]. 2011 Oct [cited 2011 Sep 6];21(suppl 3):[about 1 p.].
Available from:
.
