Mutational heterogeneity in cancer
CCL=chronic lymphocytic leukemia; DLBCL=diffuse large B-cell lymphoma.
Lawrence MS, et al. Nature. 2013:499;214-218.
22
20
52
134
26
23
81
227
91
57
121
13
63
214
11
394 219
20
49
181 231
76
88
35
335 179 121
n=
Somatic mutation frequency (/Mb)
1,000
100
10
1
0.1
0.01
Rhabdoid tumor
Ewing sarcoma
Thyroid
Acute myeloid leukemia
Medulloblastoma
Carcinoid
Neuroblastoma
Prostate
CCL
Low-grade glioma
Breast
Pancreas
Multiple myeloma
Kidney clear cell
Kidney papillary cell
Ovarian
Glioblastoma multiforme
Cervical
DLBCL
Head and neck
Colorectal
Esophageal
adenocarcinoma
Stomach
Bladder
Lung adenocarcinoma
Lung SQ cell carcinoma
Melanoma
Beyond the histology
