Evaluation of PD-L1 expression in NSCLC
Evaluation in primary NSCLC
•
Higher PD-L1 positivity in squamous cell than adenocarcinoma
–
39% vs 18%
•
Higher PD-L1 positivity associated with higher smoking intensity
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Never smoked or ≤10 pack years (PY): 10%
–
0–45 PY: 22%
–
>45–180 PY: 34%
•
Low PD-L1 expression in
EGFR
mutation-positive patients
–
14% (vs 28% for all patients)
Comparison of primary NSCLC, nodes, and metastasis
•
High levels (89%) of concordance of PD-L1 expression in primary NSCLC and N nodes
•
High levels (77%) of concordance of PD-L1 expression in primary NSCLC and metastasis
Mitchell P, et al. Presented at WCLC 2015, Oral 13.06.
Beyond the histology
