THE PRECISION APPROACH:
TARGET EGFR
2004
2008
TIME LINE
Saltz
Cunninghan
Lenz
Jonker
Wierzbicki
2004
2004
2006
2007
2007
Phase
II
II/III
II
III
II
Stained
≥1%
Positive
Strat
Strat
Neg
Response rate
8,8%
10,8%
11,6%
8,0%
8,2%
EGFR HAVE NOT PREDICTIVE
RESPONSE CAPACITY
Saltz LB. J Clin Oncol. 2004
Cunningham D. N Engl J Med.2004
Lenz HJ.J Clin Oncol 2006
Jonker DJ. N Engl J Med. 2007
Wierzbicki R. ASCO Meeting. 2008
Cmab
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