Inmunoterapia en 1L del CPCNP: monoterapia y/o tratamiento combinado - page 26

Juergens RA, et al. WCLC 2016
ORR=61,5%
All causality (N=26) Related to
Pem/Cis Related to D ± T
All ≥ G3 All ≥ G3 All ≥ G3
Febrile Neutropenia 1 (4%) 1 (4%) 1 (4%) 1 (4%) - -
Mucositis 4 (15%) - 4
(15%) - 1 (4%) -
Vomiting 16 (62%) 2 (8%) 15
(58%) 2 (8%) 6
(23%) -
Diarrhea 9 (35%) 3 (12%) 4
(15%) 1 (4%) 4
(15%) 1 (4%)
Rash 9 (35%) 1 (4%) 7
(27%) 1 (4%) 4
(15%) 1 (4%)
Fatigue 26
(100%) 3 (12%) 20
(77%) 2 (8%) 13
(50%) -
Dyspnea 18 (69%) 2 (8%) 2 (8%) - 3
(12%) -
Pneumonitis 2 (8%) 1 (4%) 1 (4%) 1 (4%) 2 (8%) 1 (4%)
DLT
Hyperthyroid 2 (8%) - - - 2 (8%) -
Hypothyroid 4 (15%) - - - 3
(12%) -
Durva+CT+/-Treme=CCTG Ph1b Study