Bloqueo de la familia ERBB: TKI’s Irreversibles vs. Reversibles - page 17

Mechanism of Acquired Resistance

Wu Oncotarget 2016

20 patients (47.6%) had acquired T790M mutation.

T790M rate was not different between first-generation EGFR TKI-naïve

patients (50%) and first-generation EGFR TKI-treated patients (46.4%).

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