Tratamiento del melanoma avanzado con tafinlar (DABRAFENIB) + MEKINIST (TRAMETINIB) - page 3

MUTACIONES BRAF

Adaptado de Márquez-Rodas et al 2011

BRAF

NRAS

MEK

ERK

AKT

PI3K

mTO

PTEN

INH BRAF

SURVIVAL

PROLIFERATION

mutación cKIT 1%

MELANOMA CELL

40-50%

10-20%

Raras

20%

(pérdidas)

Raras

INH MEK

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