 
          NOAH: EFS (HER2-positive population)
        
        
          1.00
        
        
          0.75
        
        
          0.50
        
        
          0.25
        
        
          0
        
        
          0
        
        
          6
        
        
          12
        
        
          18
        
        
          24
        
        
          30
        
        
          36
        
        
          42
        
        
          Probability of EFS
        
        
          Months
        
        
          H + CTx
        
        
          CTx
        
        
          Events
        
        
          36
        
        
          52
        
        
          3-year
        
        
          EFS
        
        
          70.1
        
        
          53.3
        
        
          HR
        
        
          0.56
        
        
          95% CI
        
        
          0.36–0.85
        
        
          p value*
        
        
          0.006
        
        
          Median follow-up 3 years
        
        
          *Unadjusted for stratification variables: adjusted HR=0.55, p=0.0062
        
        
          EFS = event-free survival; CTx = chemotherapy
        
        
          Gianni, et al. Lancet 2010