Cáncer de mama precoz: el caso de la neoadyuvancia en HER2 positivo - page 18

HER2 is activated in two different ways
Overexpression:
o
Arising from gene amplification which results in
constitutive activation of HER2 (ligand independent)
o
Antagonized by trastuzumab
Co-receptor:
o
For other HER family members especially HER3
(ligand dependent)
o
Antagonized by pertuzumab
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