Neosphere
Tryphaena
TBCRC-006
Scheme
Ch
+
T
Ch
+
P
Ch
+
TP
TP
Ch
+
TP
TL
Primary
endpoint
pCR breast
Cardiotoxicity
pCR breast
n
107
94
107
108
225
66
pCR (%)
breast
29
24
46
17
62
28
pCR (%)
breast & axila
21
18
39
11
48
NR
Neoadjuvant Studies I
Ch, chemotherapy; L, lapatinib; n, sample; P, pertuzumab; pCR, pathological complete
response; T, trastuzumab
