 
          HR=0.76 (95% CI: 0.67-0.86)
        
        
          % Event -Free
        
        
          60
        
        
          40
        
        
          20
        
        
          0
        
        
          0
        
        
          2
        
        
          4
        
        
          6
        
        
          8
        
        
          10
        
        
          P<0.0001
        
        
          0
        
        
          1
        
        
          2
        
        
          3
        
        
          4
        
        
          5
        
        
          P=0.016
        
        
          Without T
        
        
          With T
        
        
          100
        
        
          80
        
        
          41.9%
        
        
          28.8%
        
        
          % Event -Free
        
        
          60
        
        
          40
        
        
          20
        
        
          0
        
        
          100
        
        
          80
        
        
          Years from Randomization
        
        
          HR=0.64 (95% CI: 0.44-0.93)
        
        
          Without T
        
        
          With T
        
        
          Years from Randomization
        
        
          Neoadjuvant
        
        
          NOAH
        
        
          Event-Free Survival
        
        
          L. Gianni et al, ASCO Annual Meeting 2013
        
        
          Adjuvant
        
        
          HERA
        
        
          Disease-Free Survival
        
        
          Roche data on file.
        
        
          Neoadjuvant key messages