OLAPARIB :
A 10 year development journey
Pre-clinical
Early-Clinical Trial:
Phase I/Expansion
Randomized Clinical
Trials : Phase II/III
Regulatory
Approval: EMA&FDA
2005
2015
BRCA
-/-
BRCA
+/-
Farmer et al, Nature 434917-921 , 2005
Bryant et al, Nature 434922-926 ,2005
Fong P
et al
.
N Engl J Med
, 2009; 361, 123-134
Fong P
et al
.
J Clin Oncol
, 2010; 28, 2512-251946
Ledermann J
et al
.
N Engl J Med
2012;366:1382–1392
Oza A. Lancet Oncol 2015; 16: 87–97; Gelmon KA
et al
. Lancet
Oncol
2011;12:852–861
