Avances terapéuticos en el tratamiento del cáncer de ovario: OLAPARIB: primer inhibidor de PARP - page 25

Liu J. et al; Lancet Oncol 2014; 15: 1207–14
Med PFS
16.5
v
19.4
m
(HR 0.55; p=0.16
95% CI 0.24-1.27)
Med PFS
5.7
v
16.5
m
( HR 0.32; p=0.008
95% CI 0.14-0.74)
BRCA mut
BRCA wt/uk
Median PFS: 9.0 mos
(95% CI 5.7–16.5) for O and
17.7
mos
(14.7–not reached) for C+ O (
HR 0.42,
95% CI
0.23–0.76, p=0.005
1...,15,16,17,18,19,20,21,22,23,24 26,27,28,29,30,31,32,33
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