1L CT (HR+HER2-): Active treatments
Anthras re-challenge (liposomal)
Taxanes (or taxane re-challenge)
Capecitabine or vinorelbine; eribulin…
Previous Anthras/taxanes
•
In patients pretreated with adjuvant taxanes and anthracyclines, other options such
as vinorelbine and capecitabine are also appropriate first-line CT options
[SEOM 2015]
•
In patients pre-treated (in the adjuvant and/or metastatic setting) with an
anthracycline and a taxane, and who do not need combination CT, single agent
capecitabine, vinorelbine or eribulin are the preferred choices
–
Additional choices include gemcitabine, platinum agents, taxanes, and liposomal
anthracyclines. The decision should be individualized and take into account different toxicity
profiles, previous exposure, patient preferences, and country availability
[ESMO 2016]
Gavila et al CTO 2015; Cardoso et al Ann Oncol 2016
