1L CT (HR+HER2-): Active treatments
Vinorelbine
Chan et al EJC 2009; Jones et al JCO 1995; Fumoleau et al JCO 1993
Fumoleau et al (1993)
.
VNB single-agent ph II (N=157) 1L
•
ORR 41% and SD 30%
•
Median TTF 6 mo and median OS 18 mo
•
AEs: N&V, anemia, thrombopenia
Vogel et al (1999).
VNB single-agent ph II >60yr (N=56) 1L
•
ORR 38%, median DoR 9 mo and median TDP 6 mo
•
AEs: neutropenia and other haematologic
