1L CT (HR+HER2-): Active treatments
•
Anthras. or taxanes, either alone or in combinations, are considered 1L CT of choice,
particularly in pts without prior adjuvant CT or with late relapses
[SEOM 2015]
•
In the absence of medical contraindications or pt concerns, anthra. or taxane based
regimens, preferably as single agents, would usually be considered as 1L CT for HER2-
MBC, in those pts who have not received these regimens as (neo)adjuvant treatment and
for whom CT is appropriate.
–
Other options are, available and effective, such as capecitabine and vinorelbine,
particularly if avoiding alopecia is a priority for the pt
[ESMO 2016]
Gavila et al CTO 2015; Cardoso et al Ann Oncol 2016;
