Anti-PD1 and anti-PDL1 therapies in previously
treated advanced NSCLC: trial design
Brahmer, et al. N Engl J Med 2015 373(2): 123–35; Borghaei, et al. N Engl J Med 2015 373(17): 1627–39
Herbst, et al. Lancet 2016 387(10027): 1540–50; Barlesi, et al. ESMO 2016 (Abs.LBA44)
NSCLC Stage IV (2L/3L)
1. Nivolumab
SqCC
N=272
2. Nivolumab
NSq
N=582
3. Pembrolizumab
>1%
N=1024
4. Atezolizumab
Any
N=1225
Docetaxel
Checkpoint
inhibitor
R
1:1