Early
vs
Late Progressors:
Mechanistic Hypothesis
Rapidly progressing adenocarcinomas
depend more strongly on vascularization
for oxygen and nutrient supply
than slowly growing tumors
High-level
production
of angiogenic growth
factors by tumor
cells
High intrinsic rate of tumor cell proliferation
(oncogenome-dependent)
RAPID
DISEASE
PROGRESSION
High-level
angiogenesis
NINTEDANIB
Reck M, WCLC 2016
