ROS-1 population
TPM3-ROS1
SDC4-ROS1
CD74-ROS1
EZR-ROS1
LRIG3-ROS1
ROS1
SLC34A2-ROS1
•
about 1 % of NSCLC
•
enriched in: adenocarcinoma, never-smokers, women and age < 60yo
•
Many partners have been identified for ROS1, the most common CD74
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Testing: FISH (gold-standard), IHC (D4D6 mAb) and NGS
Bergethon K, et al. J Clin Oncol 2012; Takeuchi K, et al. Nat Med 2012; Reguart N, et al. Clin Chem 2017
