AURA 3 CNS disease
With CNS metastases
Without CNS metastases
Probability of
progression-free survival
1.0
0.8
0.6
0.4
0.2
0
0
3
6
9
12
15
18
93
51
80
32
46
9
27
4
14
2
4
0
0
0
Months
HR 0.32
(95% CI 0.21, 0.49)
Probability of
progression-free survival
1.0
0.8
0.6
0.4
0.2
0
0
3
6
9
12
15
18
186
89
160
61
116
35
61
13
36
5
9
1
0
0
Months
HR 0.40
(95% CI 0.29, 0.55)
8.5 vs 4.2 m (N=144 pts) 10.8 vs 5.6 m (n=275 pts)
Papadimitrakopoulou VA, et al. WCLC 2016
