RAS
meta-analysis
Results: OS (WT
RAS
)
Heinemann V, et al. Ann Oncol 2015;26(Suppl 4):abstract 150 (and poster).
SE, standard error.
Weight is relative weight (%) from the fixed-effect model.
CALGB
FIRE-3
PEAK
(n = 170)
Total
(fixed)
Total
(random)
HR (95% CI)
0.90
(0.70, 1.10)
0.70
(0.53, 0.92)
0.63
(0.39, 1.02)
0.79
(0.67, 0.93)
0.77
(0.63, 0.95)
−0.105
−0.357
−0.462
0.1153
0.1407
0.2453
52.8
35.5
11.7
100
logHR
logSE
Weight
Favours
EGFRI + chemo
0.1
1
Favours
Bevacizumab + chemo
10
Heterogeneity: Chi
2
= 2.87, df = 2, (P = 0.24), I
2
= 30%, Tau
2
= 0.01
(n = 526)
(n = 342)
