Adverse event profile of immune checkpoints
inhibitors therapies compared with CT
•
Anti PD-L1 vs PD-1: Pooled pneumonitis any grade 3.6% anti-PD1 and 2.2% anti-PD-L1
Checkmate 017
1
Checkmate 057
1
KEYNOTE 010
2
POPLAR
3
Nivo
(n=113)
DTX
(n=129)
Nivo
(n=287)
DTX
(n=268)
Pembro
2 mg/kg
(n=339)
Pembro
10 mg/kg
(n=343)
DTX
(n=309)
Atezo
(n=142)
DTX
(n=135)
TRAEs, %
Any grade
61
87
71
88
63
66
81
67
88
Grade 3–4
8
56
11
54
13
16
35
12
39
Grade 5
0
2
<1
<1
1
1
2
1
2
1. Borghaei H et al. Presented at ASCO 2016. 9025. 2. Herbst RS et al. Oral presentation at ESMO Asia 2015. 3. Smith D
et al. Poster presentation at ASCO 2016.
