Characterization of long-term responders on Olaparib
from study D0810C000019
Univariate Analysis:Markers of response to OLA
HRD Status( p=0.026) associated with LTR
BRCA Mutated associated with LTR
Presence of TP53 mut in 96% of LTR (p=0.051)
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Pathology Review on going
Genome Sequencing-LTR:
Somatic mutations were foud in all the LTR patients
25/28 evaluable pts had al least 2 mutations
Mostly common mutations: TP53 and BRCA
Stephanie Lheureux et al; J Clin Oncol 33, 2015 (suppl; abstr 5566)
