Eribulin Induces Mitotic Block by Inhibiting
Microtubule Growth but Not Shortening
Growing
microtubule
Shortening
microtubule
Tubulin
depolymerization
Tubulin
polymerization
Eribulin
1
Nonproductive
tubulin
aggregates
Taxanes and Vinca
alkaloids
inhibiting both growth &
shortening of microtubule
Eribulin
2
does not affect
microtubule shortening
(at lowest effective concentrations)
Eribulin
3
leads
to nonproductive
tubulin
aggregates
inhibits microtubule growth
Spindle
Pole
Modified from Jordan MA, Kamath K, et al.
Mol Cancer Ther
. 2005;
4
:1086–1095
