Vascular
remodeling
Antimitotic
effects
Known activity
New activities
Tumor
EMT
reversal
Antimitotic mechanism
• Antimitotic effects directly kill cancer
cells
1-3
Effects on tumor biology
• Tumor vasculature remodeling
4-7
– Eliminates hypoxia in tumor core
– Hypoxia is a key driver of EMT
• EMT reversal
7,8
– Change to less aggressive epithelial
phenotype
• Reduced Aggressiveness and
Metastatic Potential
7,8
• Greater tumour visibility by the immune
system
9
Eribulin may cause Tumour Biology Changes
1.
Jordan MA, et al.
Mol Cancer Ther
. 2005;4:1086–1095.
2.
Okouneva T, et al.
Mol Cancer Ther
. 2008;7:2003–2011.
3.
Towle MJ, et al.
Cancer Res
. 2001;61:1013–
1021.
4.
Funahashi Y, et al
. Cancer Sci.
2014;105(10):1334-42.
5.
Agoulnik SI, et al.
Vasc Cell
. 2014;6:3.
6.
Ueda S, et al.
Br J Cancer
. 2016 May 24;114(11):1212-8.
7.
Kawano S, et al. Anticancer Res. 2016;36(4):1553-61.
8.
Yoshida T, et al.
Br J Cancer
2014;110:1497-1505.
9.
Goto W, et al., AACR 2016 (abstract 5127).
