Most common treatment-related adverse events: diarrhoea,
fatigue, nausea, decreased appetite and abdominal pain
Onset of diarrhoea was a median of 7 days from initiation of
therapy, with a median duration of 7.5 days for Grade 2 and 4.5
days for Grade 3 (20%)
MONARCH 1: Safety
AE, n (%)
Abemaciclib 200 mg
N = 132
SAEs
32 (24.2)
AEs leading to study drug discontinuation
10 (7.6)
AEs with outcome of death
During therapy
Within 30 days after discontinuation
3 (2.3)
2 (1.5)
1 (0.8)
Dickler M, et al. ASCO 2016
