CDK, cyclin-dependent kinase.
FGFR, fibroblast growth factor receptor; CDK, cyclin-dependent kinase; PI3K, phosphatidylinositol-4,5-
bisphosphate 3-kinase; PTEN, phosphatase and tensin homologue; AKT, protein kinase B; mTOR, mammalian
target of rapamycin; ERK, extracellular-signal-regulated kinase
1. Turner N, et al. Cancer Res 2010;70:2085–94;
2. Roidl A, et al. Clin Cancer Res 2009;15:2058–66.
FGFR
Sustained proliferative
signalling
CDKs
PI3K/AKT/mTOR
MAPK/ERK
Mechanisms of Acquired Resistance…
