B CDK1
A CDK1
A CDK2
E CDK2
Extent of Rb
phosphorylatio
n
dephosphorylation
D CDK4/6
Target of CDK4/6
inhibitors
hyperphosphorylati
on
Inactivates Rb
and allows
progression
p16
INK4a
Preclinical predicator of sensitivity
-
High Cyclin D1
-
High Rb
-
Low p16
Finn, et al. Breast Cancer Res. 2009
Biomarker analysis
