Terapias dirigidas en combinación con hormonoterapia en cáncer de mama avanzado HER2- negativo - page 10

 Activation of signaling
through PI3K/mTOR
 GF receptor crosstalk
 Ligand independent
signaling
 Increase in GFs (ligand)
 Mutational activation of
PI3K
Mechanisms of AI Resistance
10 | GMA Medical Directors Meeting | 25 April 2013| Rome, Italy.
D-cyclin
R R
Ras
RAF
MEK
ERK
PI3K
AKT
mTOR
PTEN
CDK4/6
pRb
E2F
G1 S
p16
DHFR TS
Cyclin E
CDK2