Alpelisib Breast Cancer Program Overview
Combination
Neo-adjuvant
mBC
Letrozol
Fulvestrant
TAM +
goserelin
T-DM1
CBYL719A2201
:
Letrozole ± BKM120 or
BYL719
(Phase II)
Registration Trial
38
CBYL719XUS03T
Letrozole + BYL719
(Phase Ib)
CLEE011X2107
:
Letrozole + LEE011 ±BYL719
(Phase I/II)
CBYL719X2101
Fulvestrant+ BYL719
(Phase I)
CLEE011X2108
:
Fulvestrant + LEE011 ±
BKM120 or BYL719
(Phase I/II)
SOLAR-1
Fulvestrant ± BYL719
(Phase III) (1/2L)
B-YOND:
TAM + Goserelin with
BKM120 or BYL719
(Phase Ib)
BYL719 +T-DM1
(Phase Ib)
1
6
0
9
0
4
3
6
8
1
