Concur: Overall survival (OS)
        
        
          Primary endpoint
        
        
          1.00
        
        
          0.75
        
        
          0.50
        
        
          0.25
        
        
          0.00
        
        
          0
        
        
          100
        
        
          200
        
        
          300
        
        
          400
        
        
          500
        
        
          600
        
        
          OS probability
        
        
          Days from randomization
        
        
          Events,
        
        
          n
        
        
          (%)
        
        
          95 (69.9)
        
        
          60 (88.2)
        
        
          Median, months
        
        
          8.8
        
        
          6.3
        
        
          HR [95% CI]
        
        
          0.550  [0.395 ‒ 0.765]
        
        
          P
        
        
          = 0.0002 (1-sided)
        
        
          Regorafenib
        
        
          (
        
        
          n
        
        
          =136)
        
        
          Placebo
        
        
          (
        
        
          n
        
        
          =68)
        
        
          45% reduction in risk of death
        
        
          in the regorafenib group
        
        
          J. Li, et al. WCGI 2014. Abstract O-0023. Presented at WCGI 2014, Barcelona, Spain