Immunotherapy in BC: How?
Hayden. Nature 2012
T cell receptor
recognises tumour
cell
PD-L1 binds
PD-1, inhibiting
T cell response
A separate therapy uses
antibodies that bind PD-
L1 on the tumour cell
Antibodies block
inhibitory signal to
PD-1
T cell
Tumour
cell
T cell
Tumour
cell
PD-L1
PD-1
TCR
MHC
PD-L1
PD-1
