Summary of TRAEs
Patients, n (%)
TRAE
<70 years
(n = 830)
≥70 years
(n = 544)
ECOG PS
0−1
(n =
1,230)
ECOG PS
2
(n = 123)
Any grade
499 (60)
339 (62)
a
766 (62)
a
58 (47)
Grade 3−4
90 (11)
73 (13)
146 (12)
13 (11)
Spigel D, et al. WCLC 2016
Rates of grade 3−4 TRAEs were low across age and ECOG PS subgroups
In patients with ECOG PS 2, frequencies of overall TRAEs, individual TRAEs
(fatigue, nausea, hypothyroidism, rash, and arthralgia), and select TRAEs
(skin, endocrine, and pulmonary categories) were lower than in patients
with ECOG PS 1
PS
2
PS
2
PS
2
PS
2
PS
2
PS
2
Fatigue
Diarrhea
Nausea
Rash
Arthralgi
a
Most frequently
reported TRAEs
a
Hypothyroidis
m
Decreased
appetite
Patients (%)
0
4
8
12
16
20
24
28
32
36
40
PS 0−1
PS 0−1
PS 0−1
PS 0−1
PS 0−1
PS 0−1
PS 0−1
PS
2
