Symptom Burden and
Health-Related QoL Over Time by Subgroup
0
5
10
15
20
25
30
35
40
45
50
0
6
12
18
24
30
36
LCSS symptom burden index
Mean LCSS symptom
burden index score
Weeks
No. of patients
≤70 years
633
578
407
286
220
164
113
341
312
230
167
133
98
54
>70 years
PS 0-1
PS 2
570
522
355
195
91
43
10
33
30
17
8
4
2
1
Mean EQ-5D VAS
0
10
20
30
40
50
60
70
80
90
100
0
6
12
18
24
30
36
EQ-5D VAS
≤70 years
>70 years
ECOG PS 0-1
ECOG PS 2
Weeks
631
572
401
285
221
160
108
339
3 11
229
166
129
95
55
566
516
352
193
89
41
11
32
28
16
7
4
1
1
Spigel D, et al. WCLC 2016
