 
          Pathological Complete Response in Breast
        
        
          (ypT0/is)
        
        
          NeoSphere
        
        
          H, trastuzumab; P, pertuzumab; T, docetaxel
        
        
          p values from Cochran-Mantel-Haenszel test and adjusted for multiplicity
        
        
          p=0.0198
        
        
          TH
        
        
          THP
        
        
          HP
        
        
          TP
        
        
          p=0.0141
        
        
          50
        
        
          40
        
        
          30
        
        
          20
        
        
          10
        
        
          0
        
        
          pCR, %
        
        
          
        
        
          95% CI
        
        
          p=0.003
        
        
          29.0
        
        
          45.8
        
        
          16.8
        
        
          24.0
        
        
          N=107
        
        
          N=107
        
        
          N=107
        
        
          N=96
        
        
          Gianni L. et al.  Lancet Oncol 2012